Fig. 4
From: Comparative transcriptome in large-scale human and cattle populations
Comparison of inter-individual variability of gene expression and their cis-genetic regulatory effects. a Hierarchical clustering of tissues in humans and cattle based on Pearson’s correlation of median absolute deviation (MAD) of expression. b Percentage of orthologous genes shared in each bin between humans and cattle. Genes were ranked (from largest to smallest) by MAD, and then divided into ten bins (1731 genes per bin). c Distribution of top cis-eQTLs around transcriptional start sites (TSS) in human and cattle liver. d Number of eGenes (genes with significant cis-expression quantitative trait loci, cis-eQTLs) in what number of tissues in cattle (left) and humans (right). There is a weak but significant correlation (Spearman’s r =0.15; p = 1.91×10−13) between the number of tissues an eGene was detected on across both species e, Enrichment of eGenes between human and cattle tissues. Color represents −log10FDR. P-values are computed using the hypergeometric test for the overlaps of eGenes between human and cattle tissues, and then are adjusted for multiple testing with FDR method. “*” represents FDR < 0.05. f Distribution of difference in median absolute deviation (MAD) between humans and cattle among four groups of genes in blood, i.e., cattle-specific eGenes (cattle), human-specific eGenes (human), species-shared eGenes (both), and non-eGenes in neither species (neither)