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Fig. 8 | Genome Biology

Fig. 8

From: Single-cell diploid Hi-C reveals the role of spatial aggregations in complex rearrangements and KMT2A fusions in leukemia

Fig. 8

CRGs show active transcriptions, proximity to loop anchors, and high levels DSBs. A–C The relationship between DBS frequency in a gene and distance to chromosomal loop anchors. In each plot, the expression level is denoted with colors, and CRGs are marked using dark green circles. D Comparison of the distances to nearest loop anchors among KMT2A partners, CRGs, and other genes. E The heatmap of CRG expression in blood cells, and the gene expression is normalized as percentile in each single cell. F CTCF enrichment, transcriptional activity, and ETO-treated breakages in genomic regions around SRSF4 gene in K562 cells. G Genome-wide ETO-treated DSB profiles of the SEC14L1 gene in TK6 cells treated with or without DRB (a transcription inhibitor)

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