Fig. 8From: Single-cell diploid Hi-C reveals the role of spatial aggregations in complex rearrangements and KMT2A fusions in leukemiaCRGs show active transcriptions, proximity to loop anchors, and high levels DSBs. A–C The relationship between DBS frequency in a gene and distance to chromosomal loop anchors. In each plot, the expression level is denoted with colors, and CRGs are marked using dark green circles. D Comparison of the distances to nearest loop anchors among KMT2A partners, CRGs, and other genes. E The heatmap of CRG expression in blood cells, and the gene expression is normalized as percentile in each single cell. F CTCF enrichment, transcriptional activity, and ETO-treated breakages in genomic regions around SRSF4 gene in K562 cells. G Genome-wide ETO-treated DSB profiles of the SEC14L1 gene in TK6 cells treated with or without DRB (a transcription inhibitor)Back to article page