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Fig. 2 | Genome Biology

Fig. 2

From: Single-cell diploid Hi-C reveals the role of spatial aggregations in complex rearrangements and KMT2A fusions in leukemia

Fig. 2

The 3D spatial structures between KMT2A and fusion partners. A The boxplots of Euclidean distances among single cells between KMT2A and its 14 closest fusion partners. B The co-localizations of KMT2A and different fusion partners in each cell. C The colocalization correlations across cells between different KMT2A partners. D The P-values computed from the comparisons of the distances to KMT2A between partner genes and the other genes in a single cell as well as the average and minimum distances among the groups. E–G GSEA results of GM12878 Cell 2 and average, minimum of all single-cells. H The colocalization network of the top 30 KMT2A fusion partners which have the largest numbers of colocalized partners. A darker color for a node (except KMT2A gene, which is highlighted by green) means more connections in the network. I Transcriptional enrichments of the top 30 KMT2A fusion partners using Enrichr. J Most of the top 30 partners are the targets of transcription factors RUNX1 and CEBPD

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