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Fig. 1 | Genome Biology

Fig. 1

From: ZetaSuite: computational analysis of two-dimensional high-throughput data from multi-target screens and single-cell transcriptomics

Fig. 1

Overview of the ZetaSuite workflow. a Two-dimensional screens include high-throughput screen by high through sequencing (HTS2), high-content screen, parallel genome-wide screens, etc. ZetaSuite uses the raw matrix as input to calculate ζ score. b–g Key steps in the ZetaSuite method from generating initial ζ scores (b) to deducing hits by using negative and positive controls to derive a support vector machine (SVM) learning curve (c) to calculating weighted ζ scores (d) to determining the Screen Strength (e) to filtering out off-targets (f). The resulting data are used to construct regulatory gene networks based on functional similarities (g)

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