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Fig. 4 | Genome Biology

Fig. 4

From: High-throughput techniques enable advances in the roles of DNA and RNA secondary structures in transcriptional and post-transcriptional gene regulation

Fig. 4

Functional roles of secondary structures in transcription termination. a Juxtaposition of the poly(A) signal and the polyadenylation sequence [160, 163]. Formation of a hairpin structure brings the poly(A) signal in closer proximity to the polyadenylation sequence, resulting in higher expression levels. b Modulation of miRNA binding [164,165,166]. c Formation of the secondary structure enables transcript localization [161], d. Modulation of alternative polyadenylation by structure formation [167]. e R-loop formation at the 3’UTR promotes transcription termination. f Concealment of cis-regulatory elements [168, 169], g Exposure of cis-regulatory elements [170,171,172,173,174]

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Genome Biology

ISSN: 1474-760X

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