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Fig. 3 | Genome Biology

Fig. 3

From: High-throughput techniques enable advances in the roles of DNA and RNA secondary structures in transcriptional and post-transcriptional gene regulation

Fig. 3

Functional roles of secondary structures in promoter regulation. a Non-B DNA structure formation can mediate transcription factor binding and promote transcription [81,82,83,84,85,86]. b Non-B DNA structure formation can hinder transcription factor binding to inhibit transcription [87, 88]. c RNAP stalling at the G-quadruplex structure formed at the template strand [81, 89]. d G-quadruplex structure formation at the non-template strand enables the template strand to remain single-stranded and promotes expression [90]. e Non-B DNA structure formation can hinder nucleosome formation to promote transcription [1, 91,92,93]. f Non-B DNA structures can promote long range DNA looping [94,95,96,97,98]

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Genome Biology

ISSN: 1474-760X

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