Fig. 3

All amino acid variants identified in the RRDR of the rpoB gene by joint genotyping 8,955 samples from the CRyPTIC M. tuberculosis data set. Each plot shows the RRDR region from left to right. Single amino acid variants are shown in the upper grid, with the y axis corresponding to the variant amino acid. The lower area shows deletions and insertions, with the inserted sequence given in the colored boxes. For example, the leftmost deletion of amino acids TS at position 427-428 is found in one sample, which is resistant. The leftmost insertion adds R after the S at position 431 (found in one resistant sample). The plots show the same variants, but with different color schemes. In a each variant is colored by the number of samples possessing that variant. Plot b colors the variants by the percent of samples with that variant that are rifampicin resistant