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Fig. 8 | Genome Biology

Fig. 8

From: GoPeaks: histone modification peak calling for CUT&Tag

Fig. 8

GoPeaks detects peaks from other epigenetic profiling techniques. a Heatmap of global RUNX1 and IgG ChIP-seq signal from K562 cells per peak calling method. b Transcription factor motif enrichment for regions of global RUNX1 ChIP-seq signal. Top four known motifs are shown. c Heatmap of global SOX2 and IgG CUT&RUN signal from H1 hESC cells per peak calling method. d Transcription factor motif enrichment for regions of global SOX2 CUT&RUN signal. Dot color represents the binomial fold enrichment and color represents the -log10(p-value) of the motif. The asterisk indicates the motif p-value is less than R’s smallest representable number (1 × 10−324). e ATAC-seq was performed on Kasumi-1 cells. Overlap of peaks identified in each biological replicate by GoPeaks. f Example peaks at SSRP1 and P2RX3 genes. Peak calls for individual biological replicates are shown. Tracks are CPM normalized and are scaled to the range [0–3.11] by IGV. Tracks are depicted on the GRCh38 genome assembly

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