Fig. 6

GoPeaks captures the broad peak profiles of H3K27me3 CUT&Tag peaks. a ROC curves quantifying the recall and false positive rates and b PR curves quantifying the precision and recall rates of H3K27me3 CUT&Tag data from H3K27me3 ChIP-seq data. Both ChIP-seq and CUT&Tag datasets were generated in K562 cells. Colors indicate the peak calling method. GoPeaks and MACS2 “--broad” flags were used. c Number of high-confidence peaks identified from H3K4me3 CUT&Tag data per peak calling method. d Overlap of high-confidence peaks identified by each peak caller. e Distribution of the distances to the next nearest peak. f Example peaks at FIBCD1, LAMC3, and AIF1L genes. IgG replicates are the negative controls. Consensus peak calls for each method are shown. Tracks are CPM normalized and are scaled to the range [0–18.0] by IGV. Tracks are depicted on the GRCh38 genome assembly