Fig. 7
From: Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets
A Visualization of TEAD2 locus. Lead SNP rs1465697 (PICS of 15%) is depicted with a red line. The blue box on the left illustrates the overlap with the ATAC-seq peaks present in CD4 T (orange) and B cells (purple). The SNP and ATAC-seq peaks also overlap a PCHiC looping interaction with the promoter for the TEAD2 gene (arc; the boundaries of the enhancer/promoter regions are indicated in green; the promoter of TEAD2 is highlighted with the blue box on the right). B Gene expression of TEAD2 across immune cells available in the DICE database (https://dice-database.org/). X-axis display transcripts per million (TPM). C Cis-eQTL boxplot per genotype status of rs1465697 in naïve B cells in the DICE database (https://dice-database.org/). D Transcription factor enrichment in the GTRD database for the putative causal genes that are common in CD4 T and B cells. Each dot represents one of 526 transcription factors. The Y-axis indicates the −log10 of the FDR. The TEAD2 enrichment is highlighted (p-value = 1.34×10−8, FDR = 8.81×10−7)