Fig. 5
From: Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets
A Enrichment of MS GWAS heritability in OCRs from untreated patients with MS. Enrichment p-values are shown as −log10(p-value). B, C LDSC results for MS GWAS enrichment in a joint model for T4cm (B) and cMBc (C) OCRs from untreated patients with MS. Heights of the circles reflect stratified LDSC coefficient p-values. Sizes of the circles are proportional to the enrichment p-values for that given cell type, with larger circles reflecting more significant p-values. D Enrichment of MS GWAS heritability in OCRs from MS patients undergoing immunomodulatory treatment. Enrichment p-values are shown as −log10(p-value). Treatments include glatiramer acetate, interferon, or natalizumab