Fig. 1

A Experimental design. Top box shows the hematopoietic cell types analyzed. MS discovery GWAS results were integrated with ATAC-seq profiles generated from the hematopoietic cell types. LDSC was performed to evaluate enrichment of MS GWAS in the OCRs of each hematopoietic cell type. Statistical fine-mapping was also performed on the MS GWAS results, which were then integrated with orthogonal epigenetic data such as promoter capture HiC interactions. This integration of fine-mapping and epigenetic data allowed for identification of putative causal mechanisms at individual loci. B Enrichment of MS GWAS heritability in hematopoietic cell OCRs. Enrichment p-values are shown as −log₁₀(p-value)