Fig. 4

De novo discovery of methylation motifs in H. pylori genome using NT-seq. a-b Scatter plot of the median difference of −Log2FC between any 4mer-6mer A motif and the remaining A sites (a) and the median difference of -LogFC between any 4mer-6mer C motif and the remaining C sites (b). (Previously reported, corrected, and novel 6mA motifs are labeled in color). c Violin plot of −Log2(Normalized A to G ratio) for four sub motifs of previous reported GMRG6mA motif. d Violin plot of −Log2(Normalized A to G ratio) for eight sub motifs of GGWCN6mA motif. e Violin plot of −Log2(Normalized A to G ratio) for all previous reported and newly discovered 6mA motifs. Statistic test were performed by two-sided Mann-Whitney-Wilcoxon (MWW) test with Bonferroni correction (ns: P > 1.0e-3; ****: P ≤ 1.0e−6)