Fig. 5

scREG interprets disease associated loci. A Comparison of the enrichment of fine-mapped GWAS variants of IBD disease in the scREG predicted regulatory elements (red) against that in all peaks (blue) called by MACS2 in each subpopulations. B Interactive visualization function of scREG package. scREG will plot genes, the raw peaks from all cells, peaks of each cluster, and the predicted peak-gene association in each cluster. Figure shows the track around the variant rs11640143 and gene IRF8. The highlighted blue bar represents the location of REs that contain the variant rs11640143, and the yellow bar represents one example of different cluster-level-peaks are merged into one in the raw peak calling before clustering. C, D Comparison of the three TFs (IRF4, IRF8, and CEBPB) target genes with the upregulated genes and downregulated genes in IBD patients. The p-value and odd ratio are calculated based on Fisher’s exact test