Fig. 4
From: Refining colorectal cancer classification and clinical stratification through a single-cell atlas
Myeloid cell clusters in colon and colorectal tumors. A t-SNE of myeloid cells colored. by distinct cell types. B Heatmap showing the variable expression of myeloid specific marker genes across various myeloid cell types. C Identification of various myeloid cell subtypes based on expression of specified marker genes. D Boxplots show the distribution of cell types in two CRC bulk expression datasets, within tumors with varying CMS status [45, 48]. The whiskers depict the 1.5 x IQR. The P-values for pairwise t-tests comparisons (with Benjamini-Hochberg correction) of cell abundance across CMS are shown in the figure. E Box plot show TAMs infiltration and influence on CD8+ T cells in relation to CMS1 and CMS4. Note in GSE17536 Ythdf2 deficiency trended in CMS4 but did not reach the statistical significance. Note “NS”: P > 0.05, *P </=0.05, **P </=0.01, ***P </=0.001, ****P </=0.0001