Fig. 8
From: Strand asymmetry influences mismatch resolution during single-strand annealing
First-nick model.a After resection of the 5′ ends and annealing of the complementary strands, unannealed flaps extend in 3′. b The MSH complex recognizes the mismatches and slides to initiate strand discrimination but the flaps jam the process. Shorter flaps tend to be removed earlier, allowing for strand discrimination. c The nick or breach exposed by the removal of the flap is recognized by the MSH complex that backtracks to initiate the repair of the mismatch. d The mismatch is repaired as usual by excising and re-synthesizing the strand