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Fig. 2 | Genome Biology

Fig. 2

From: Local euchromatin enrichment in lamina-associated domains anticipates their repositioning in the adipogenic lineage

Fig. 2

LADs are dynamic features of adipogenic differentiation. a Genome browser view of LMNB1 Log2(ChIP/input) ratios (y axis range shown in brackets) and called LADs for each differentiation replicate (Rep1, Rep2) at T00, T24, and T72. Other examples are shown in Additional file 1, Fig. S3. b Pearson correlations of Log2(LMNB1 ChIP/input) ratios across the genome and of LMNB1 ChIP read counts in mapped LADs, between differentiation replicates. c Genome browser view of LADs, H3K9me3 enrichment (Log2(ChIP/input) ratio range shown in brackets), and mRNA level (read count scale shown in brackets) in the 0–72-h time course. d Percent of genome coverage and genomic properties of LADs at T00, T24, and T72. e H3K9me3 enrichment in LADs and i-LADs; bar, median; box, 25–75% percentile; whiskers, min-max; ****P < 10−4, ANOVA with Welch’s correction. f Expression level of all protein-coding genes in LADs and i-LADs; cross, mean; bar, median; box, 25–75% percentile; whiskers, min-max; ****P < 10−4, ANOVA with Welch’s correction. g Venn diagram of genome coverage by LADs at each time point

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