Fig. 5
From: scINSIGHT for interpreting single-cell gene expression from biologically heterogeneous data
Comparison of observed and integrated data of B cells from COVID-19 patients. A tSNE plots of B cells based on integrated data by scINSIGHT. Cells are colored by disease phase, inferred cluster membership, or classified cell type (by SingleR). B tSNE plots of B cells based on the observed (unintegrated) data. Cells are colored by classified cell type (by SingleR). C Adjusted Rand index of inferred clusters compared with the SingleR classification. D Integration scores of the observed and integrated data. E Percentage of five clusters identified by scINSIGHT in the 14 samples. F Expression levels of five common modules that were specifically highly expressed in the five clusters in E. G Expression of the top three genes with the largest coefficients in modules 4, 10, 3, 2, and 8. Expression levels were averaged within each cluster and then scaled across clusters