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Fig. 4 | Genome Biology

Fig. 4

From: Allele-specific expression reveals genes with recurrent cis-regulatory alterations in high-risk neuroblastoma

Fig. 4

Expression of genes with recurrent allele-specific expression that is not associated with somatic copy number alterations. The heatmap shows hierarchically clustered gene expression z-scores from 498 neuroblastoma tumors in the SEQC/MAQC-III Consortium. Of the 359 NB-ASE genes that were not associated with somatic copy number alterations (SCNAs), 316 genes were covered by at least one expression probe. Samples are labeled by clinical characteristics: MYCN amplification status (amplified, non-amplified and unknown); high-risk tumor (yes or no); International Neuroblastoma Staging System (INSS) (1, 2, 3, 4, and 4S). Difference in gene-expression between stage 4 and all other stages is indicated as log2 fold-change (log2FC). The 34 genes with absolute log2FC ≥ 0.5 and FD-corrected p-value ≤ 0.05 from Student’s t test are labeled

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