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Fig. 4 | Genome Biology

Fig. 4

From: Meta-analysis defines predominant shared microbial responses in various diseases and a specific inflammatory bowel disease signal

Fig. 4

Salivary bacteria are enriched in samples from Ulcerative colitis and Crohn’s disease. A Heat map showing 15 CD/UC “specific” ASVs with significantly higher (or lower) effect size in fecal samples of CD and UC cases compared to controls in comparison to other disease cohorts [rank-mean test on the NRMD effect sizes in 10 fecal CD and UC studies compared to other disease (n = 45)]. Columns are disease cohorts, and rows represent the CD/UC specific ASVs with colors representing the NRMD; red indicates higher abundance and blue indicates lower abundance in cases vs. controls, and white indicates ASVs not present in the study. B A word cloud was generated using dbBact (http://dbbact.org/) [41] using the increased UC/CD-specific bacteria, indicating that UC/CD-specific increased bacteria has been previously found in fecal and saliva human samples. C Venn diagram showing overlap between the 31 increased non-specific ASVs and 13 IBD-specific ASVs (red and green circles respectively) salivary obtained samples including those ASVs that are present 25% and above of the samples (blue) identified from other cohorts [AGP (left) and PRJNA38386 [42] (right) see methods section for additional details], emphasizing significant larger overlap between the IBD-specific ASVs and salivary ASVs (chi-square p < 0.05) in contrast to the disease non-specific increased ASVs

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