Fig. 2

Similarities and differences in the microbial composition between diseases. Modified Bray-Curtis distance matrix was calculated using the 731 ASV effect size ratios between cases and controls across the different disease cohorts using all samples (n = 12,838). Comparisons were performed between two disease cohorts only on ASVs found in both. This modified Bray-Curtis metric was used to build the distance matrix (A). Darker color indicates high similarity and bright color indicates low similarity. Bar colors on X and Y axes indicate the specific disease of each disease cohort, as indicated in the disease key. CD UC and IBD are all colored in dark-red but the labeling specifically indicates the disease type; however, those tend to intermix. IBD represent studies in which patients were only labeled as IBD rather than CD or UC. This matrix was then used for the generation of a principal coordinate analysis (PCoA) depicting disease cohort similarity (B, C), where disease cohorts are colored by country (B) or specific disease (C)