Fig. 7

Community composition modulates species’ gene expression. Principal component biplots of the VOGs and taxa were identified as correlated by sparse canonical correlation analysis (sCCA). The analysis was conducted on the transcriptional activity of the three most prevalent species: L. crispatus (A), L. iners (B), and G. vaginalis (C). The large circular points in each plot represent the samples. In A, these points are colored according to the combined log₁₀ relative abundance the two negatively contributing taxa (A. vaginae and G. vaginalis). In B and C, these points are colored according to the ratio of the combined relative abundances of taxa that contribute either positively or negatively to the correlation. Factor loadings of the genes (positive, blue; negative, magenta) and taxa (positive, green; negative, gold) are included in the plot. For legibility, the labels for the taxa loadings, but not the VOG loadings are displayed