Skip to main content
Fig. 5 | Genome Biology

Fig. 5

From: The contribution of evolutionarily volatile promoters to molecular phenotypes and human trait variation

Fig. 5

Genes hosting evolutionary volatile promoters have higher variance in expression between individuals. a Coefficients of variation of gene expression across GEUVADIS cell lines for genes with an entirely conserved promoter architecture between human and mouse compared to genes with at least one evolutionarily volatile promoter. *** indicates a p value < 0.001 for Mann-Whitney tests comparing genes within each evolutionary category stratified by the absence (light shading, x-axis “-”) or presence (dark shading, x-axis “+”) of a conserved promoter within the same gene. The dashed blue line shows median expression variance for conserved genes as a point of reference. Red * indicate reduced variation and black * indicate increased variation in gene expression for genes containing at least one conserved promoter relative to their counterparts with only volatile promoters. b As for GEUVADIS but comparing the median coefficient of variation across GTEx tissues

Back to article page