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Fig. 7 | Genome Biology

Fig. 7

From: HyperChIP: identification of hypervariable signals across ChIP-seq or ATAC-seq samples

Fig. 7

Applying HyperChIP to non-cancer ChIP/ATAC-seq data sets. a, b PCA results for the CTCF ChIP-seq data set, which comprised samples of 17 human LCLs with different populations of origin. PCA is performed either a with all peak regions or b with only the identified HVRs as features. c PCA results for the mouse ATAC-seq data set, which comprised samples of preimplantation embryos at different development stages and mESCs. Only the identified HVRs are used as features. d Heat map showing the TF activity scores of the top 30 binding motifs identified for the early/late-stage defined in c. e Bar plots showing the TF activity scores and expression levels of Rarg and Obox3, both of which are top-ranked TFs associated with the early stage. TF activity scores have been averaged across biological replicates for each individual cell stage. FPKM, fragments per kilobase of transcript per million fragments mapped. f Bar plots showing the TF activity scores and expression levels of Sox2 and Klf4, both of which are top-ranked TFs associated with the late stage

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