Fig. 4

Systems-level properties of cancer and healthy drivers. Comparisons of systems-level properties between (a) canonical or candidate cancer drivers and the rest of human genes, (b) tumor suppressors and oncogenes, and (c) cancer genes with coding driver alterations and cancer genes with non-coding driver alterations. The normalized property score was calculated as the normalized difference between the median (continuous properties) or proportion (categorical properties) values in each driver group and the rest of human genes (the “Methods” section). Comparisons of systems-level properties between (d) candidate oncogenes with non-coding driver alterations (324) and canonical tumor suppressors, (e) candidate oncogenes (1405) and canonical tumor suppressors, and (f) candidate tumor suppressors (1318) and canonical oncogenes. g. Comparisons of systems-level properties between canonical healthy, candidate healthy, and remaining healthy drivers and the rest of human genes. Proportions of old (pre-metazoan), duplicated, essential genes, and proteins involved in the complexes were compared using a two-sided Fisher’s exact test. Distributions of gene and protein expression, protein-protein, miRNA-gene interactions, and germline variation were compared using a two-sided Wilcoxon rank-sum test. False discovery rate (FDR) was corrected for using Benjamini-Hochberg