Fig. 2

Distribution of driver annotations by organ system. a Correlation between numbers of sequenced donors and identified cancer drivers across organ systems. Spearman correlation coefficient R and associated p-value are shown. b Number of canonical, candidate, and healthy drivers in each organ system. Horizontal lines indicate the median number of canonical (92), candidate (160), and healthy (17) drivers across organ systems. c Proportion of canonical drivers detected in each organ system over canonical drivers detected in all cancer screens (421). The horizontal line indicates the median across all organ systems (22%). d Proportion of genes with non-coding driver alterations over all cancer drivers in each organ system. The horizontal line indicates the median across all organ systems (4%). Number of canonical (e), candidate (f), and healthy (g) drivers across screens and organ systems. Representative genes with different recurrence between cancer and healthy tissues are indicated. h Organ system distribution of the top eight recurrent healthy drivers. The full list is provided as Additional file 6, Table S5. i Correlation between numbers of sequenced donors and identified healthy drivers across organ systems. Spearman correlation coefficient R and associated p-value are shown