Fig. 4

The WID relative epithelial age in post-menopausal women is influenced by hormone replacement therapy. a WID-REA with respect to hormone replacement therapy (HRT) in cervical samples from post-menopausal cancer-free controls and cancers from Validation set 1. The general and epithelial clocks versus HRT treatment duration in cervical samples post-menopausal b cancer-free controls, c breast, and d ovarian cancer from Validation set 1. e WID-REA with respect to HRT in matched cervical, buccal, and whole blood in post-menopausal samples from Validation set 2. The general and epithelial clocks in f cervical, g buccal, and h whole blood in post-menopausal samples from Validation set 2. *p 0.05; **p 0.01 in paired Wilcoxon tests