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Fig. 3 | Genome Biology

Fig. 3

From: Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock

Fig. 3

A discordance between the general and epithelial clock indicates breast cancer risk in cervical samples and tissue at risk in premenopausal women and can be rescued with progesterone antagonist treatment. a, b WID-relative-epithelial-age (WID-REA; difference between general and epithelial clock, a), and visualization of the general, epithelial, and immune clocks (after adjustment for age and ic, b) in cervical samples of pre-menopausal healthy controls and cancer cases in Validation set 1. c, d WID-REA, general, and epithelial clocks in breast tissue: normal breast tissue, normal-adjacent breast tissue samples from women with triple-negative breast cancer, normal breast tissue from BRCA mutation carriers, and samples before and after treatment with the potential breast cancer preventive drugs ulipristal acetate or mifepristone. Ulipristal acetate treatment was carried out in women at high risk of breast cancer (> 17% life-time breast cancer risk based on the Tyrer-Cuzick model). Mifepristone treatment was carried out either in healthy controls or BRCA mutation carriers. Samples before mifepristone treatment are a subset of the 36 normal breast tissue samples and 30 breast tissue samples from BRCA mutation carriers. *p value 0.05; **p value 0.01 in one-way ANOVA with Tukey’s post test (a, b). *p value 0.05 in Wilcoxon test (unpaired or paired, for top and bottom graph in c and d, respectively)

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