Fig. 3From: Evaluating statistical approaches to define clonal origin of tumours using bulk DNA sequencing: context is everythingExample of allele-specific copy number changes. The top panel shows an example of copy number changes with B-Allele Frequency. The bottom panel shows an example of mirrored subclonal allelic imbalance. This term is used when within the same tumour, one subclone has gained or lost the maternal allele but the other subclone has gained or lost the paternal allele of the same chromosome, indicative of a parallel evolutionary events. Only high depth sequencing data can estimate with this level of resolutionBack to article page