Fig. 4
From: scDALI: modeling allelic heterogeneity in single cells reveals context-specific genetic regulation
scDALI-Het identifies time-specific intra-lineage variation. a Scatter plot of negative log P-values for scDALI-Het versus a scDALI test for time-specific variation in the muscle population. Red circle highlights region chr2R:13675707-13676707. b Of 363 peaks identified by scDALI-Het that are accessible in the muscle, 19% showed significant temporal effects (FDR < 0.1). c The majority of peaks with a time-specific effect in the muscle did not show significant differential allelic imbalance between lineages. d Temporal order for the muscle lineage estimated by the variational autoencoder model. e, f Estimated allelic rates across time for region chr2R:13675707-13676707. Black dots denote cells with observed allele-specific counts in this region