Fig. 2

Proportion of variance explained (PVE) by the predicted transcriptome. a The ratio of PVE (the proportion of phenotypic variation explained by the predicted transcriptome) of GTEx EUR transcriptome model over the chip heritability using whole blood on the left and using 10 tissues on the right. The 10 tissues with highest sample sizes were selected from GTEx (muscle, adipose, tibial artery, breast, lung, fibroblast, lung, tibial nerve, and skin, with sample sizes ranging from 337 to 602). Notice that in general we used GTEx whole blood and MESA monocyte-based predictors except for this panel where we used 10 tissues from GTEx. b The PVE of MESA EUR-based predicted transcriptome (x-axis) and MESA AFHI-based predicted transcriptome (y-axis) are shown. Each panel presents the results calculated in one ancestry group and each point presents one trait