Fig. 4

DNAm of clock CpGs and expression of trans-genes across sorted blood cell types. Per gene-CpG pair, the t-statistic of their association is shown in the blue-red heatmap (red = positive association, blue = negative association, white = no significant association). Only CpGs which associated with at least 10 genes and genes which associated with at least 5% of any clock were included. Genes and CpGs were clustered based on Euclidean distance. Two sidebars (viridis color scale) were included with external data, with the left sidebar depicting expression of trans-genes in 17 sorted blood cell types published by Monaco et al. [25], and the top sidebar depicting DNAm of clock CpGs in sorted T cell and NK cell subtypes combined from 4 datasets [13, 26,27,28]. For visualization, external gene expression and DNAm data were normalized so that each gene/CpG had a range between 0 and 1 across all measured cell types