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Fig. 6 | Genome Biology

Fig. 6

From: Using synthetic chromosome controls to evaluate the sequencing of difficult regions within the human genome

Fig. 6

HLA typing performance. a Read alignment for Hiseq X Ten/PCR-free (purple), Nextseq 500/PCR-based (blue), MGISEQ-2000 (yellow), and ONT PromethION (green) at exons 2 and 3 (G-group) of the HLA-A gene representation of the in silico chromosome. Immune repertoire analysis. b The schematic figure indicates the design of sequins for the TCRB gene loci. c Observed versus expected clonotype frequencies for quantification of the CDR3 region at different TCRs and BCRs, with dashed lines indicating a slope of 1

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Genome Biology

ISSN: 1474-760X

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