Fig. 4
From: MultiMAP: dimensionality reduction and integration of multimodal data
MultiMAP integration of multiple modalities of mouse brain cell data. a MultiMAP visualization of scRNA-seq [24] and spatial STARmap [25] (n = 2) data of the mouse brain, colored by omic technology, and joint clusters identified with the MultiGraph. b Dot plot showing mean log-normalized gene expression of known markers of each identified joint cluster. The top dot in each row represents cells from the scRNA-seq data, and the bottom dot represents cells from the scATAC-seq data. c Riverplot showing correspondence between the joint clusters, and the independent annotations of the scATAC-seq and scRNAseq data. d Spatial locations of the STARmap cells, colored by the joint clusters. e UMAP and MultiMAP visualizations of the STARmap dataset. The silhouette score as employed here quantifies the separation of clusters, and the higher value for MultiMAP shows the better cluster separation as compared to UMAP. f MultiMAP visualization of the integration of single-cell transcriptomics, chromatin accessibility, and DNA methylation of the mouse primary cortex, colored by omic technology and the published cell type annotation [26]