From: sPLINK: a hybrid federated tool as a robust alternative to meta-analysis in genome-wide association studies
Minor allele
Major allele
Case
\(\frac {(t+q) \times (t+r)}{2n}\)
\(\frac {(t+q) \times (q+s)}{2n}\)
Control
\(\frac {(r+s) \times (t+r)}{2n}\)
\(\frac {(r+s) \times (q+s)}{2n}\)