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Table 2 Comparison between sPLINK and the state-of-the-art approaches

From: sPLINK: a hybrid federated tool as a robust alternative to meta-analysis in genome-wide association studies

Tool/Study Privacy-aware Robust to heterogeneity Computationally efficient Linear regression Logistic regression
PLINK
Meta-analysis
Kamm et al. [17] *
Cho et al. [18] *
Morshed et al. [23]
Kim et al. [24]
GLORE [28]
sPLINK
  1. *The study supports the Cochran–Armitage test, which is computationally comparable to linear regression