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Fig. 2 | Genome Biology

Fig. 2

From: sPLINK: a hybrid federated tool as a robust alternative to meta-analysis in genome-wide association studies

Fig. 2

Architecture of sPLINK: (1) The coordinator creates a new project through the WebApp component and (2) invites a set of cohorts to join the project; (3) the cohorts join the project and select the dataset using the client component. The project is started automatically, when all cohorts joined. The computation of the test results is performed in a an iterative manner, where the clients (4) obtain the global parameters from the server, (5) compute the local parameters, mask them with noise, and share the noise and noisy local parameters with the compensator and server, respectively; (6) the compensator aggregates the noise values and sends the aggregated noise to the server; the server calculates the global parameters by aggregating the noisy local parameters and the negative of the aggregated noise; (7) after the computation is done, the cohorts and coordinator can access the results. All communications are performed in a secure channel over HTTPS protocol. The cohorts can use Linux distributions, Microsoft Windows, or MacOS to run the client component

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