Fig. 6

Myeloproliferative neoplasm GWAS enrichment for DNase I hotspots and consolidated histone mark broadPeaks from Roadmap Epigenomics consortium data: (A) Significant tissue- and cell type-specific enrichment results (q value < 0.01, Benjamini-Hochberg (BH) correction) for FORGE2 DNase I hotspot analysis on 25 suggestive MPN GWAS associations (p value < 1 × 10⁻⁶). Different tissues and cell types (rows) are grouped according to related tissue or cell type categories (e.g. white blood cell categories are placed together, as are fibroblast categories, etc.). FORGE2 DNase I hotspot analysis reveals a cell type-specific enrichment profile for CD34+ haematopoietic stem cells (red dot). (B) Significant tissue- and cell type-specific enrichment results (q value < 0.01, Benjamini-Hochberg (BH) correction) for FORGE2 histone mark broadPeak analysis for the same variants. Different tissues and cell types (rows) are grouped according to related tissue or cell type categories (e.g. white blood cell categories are placed together, as are fibroblast categories, etc.). Here, FORGE2 analysis reveals a cell type-specific enrichment profile for CD34+ haematopoietic stem cell H3K4me1 broadPeaks, a mark enriched for enhancer regions (red dot). A zoomable version of this figure can be found at: https://www.easyzoom.com/imageaccess/3245f515d6894a8eb644b35ea22b2ef5