Fig. 3

Shared and distinct tissue-specific enrichments for histone mark broadPeaks from consolidated Roadmap Epigenomics consortium data: (A) 231 tissue-specific enriched phenotypes from histone mark broadPeaks are shared with the set of enriched phenotypes for DNase I hotspot data for the same tissues, including examples for brain (central panel, self-reported math ability -MTAG-, H3K4me1 and H3K4me3 enrichment), heart (atrial fibrillation, H3K4me1 and H3K4me3 enrichment), kidney (estimated glomerular filtration rate or eGFR, H3K4me3 and H3K36me3 enrichment), and thymus (family history of Alzheimer’s, H3K9me3 enrichment). (B) 265 tissue-specific enriched phenotypes from histone mark broadPeaks are not shared with the set of enriched phenotypes for DNase I hotspot analysis for the same tissues, including examples for brain (central panel, cognitive performance H3K4me1 enrichment), heart (electrocardiographic traits, H3K4me1 enrichment), and thymus (nodular sclerosing Hodgkin lymphoma or NSHL H3K36me3 enrichment). PR interval (P wave to initiation of QRS complex interval), QT interval (Q wave to end of T wave interval), RBCs (red blood cells), WBCs (white blood cells), MTAG (multi-trait analysis of GWAS), NSHL (nodular sclerosis Hodgkin's lymphoma), Apolipoprotein E allele E4 (APOE e4). Tissue images used here are from Roadmap Epigenomics Consortium et al., 2015 [6]. A zoomable version of this figure can be found at: https://www.easyzoom.com/imageaccess/196e07438d2f48f6b24cb378d65f31b7