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Table 5 RMSE, precision, and recall obtained by Flimma and the meta-analysis tools on TCGA-BRCA datasets split by tissue source sites

From: Flimma: a federated and privacy-aware tool for differential gene expression analysis

The number of cohorts

3

5

7

10

14

RMSE

 Flimma

0.0008

0.0007

0.0008

0.0017

0.0012

 Fisher

0.94

1.82

2.53

3.86

5.37

 Stouffer

1.47

2.21

2.87

4.26

5.68

 REM

2.73

3.68

4.75

7.21

8.50

 RankProd

5.16

8.19

11.32

18.92

23.50

Precision

 Flimma

1.00

1.00

1.00

1.00

1.00

 Fisher

0.85

0.88

0.90

0.93

0.95

 Stouffer

0.85

0.88

0.91

0.93

0.95

 REM

0.93

0.94

0.95

0.97

0.97

 RankProd

0.92

0.87

0.90

0.93

0.95

Recall

 Flimma

1.00

1.00

1.00

1.00

1.00

 Fisher

0.92

0.95

0.95

0.96

0.97

 Stouffer

0.89

0.93

0.94

0.96

0.97

 REM

0.93

0.96

0.97

0.98

0.98

 RankProd

0.87

0.96

0.96

0.96

0.97

  1. Values corresponding to the best performance over all methods are italicized