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Table 1 Statistical methods employed in single-cell CRISPR screen analysis. Parametric methods are non-robust to misspecified gene expression distributions, and classical nonparametric methods cannot adjust for confounders. Conditional resampling (implemented in this work as SCEPTRE) addresses both challenges

From: SCEPTRE improves calibration and sensitivity in single-cell CRISPR screen analysis

Method class Example Robust to expression model misspecification Able to adjust for confounders
Parametric Monocle [16] No Yes
Nonparametric Virtual FACS [8] Yes No
Conditional resampling SCEPTRE Yes Yes