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Fig. 5 | Genome Biology

Fig. 5

From: SCEPTRE improves calibration and sensitivity in single-cell CRISPR screen analysis

Fig. 5

SCEPTRE discovers biologically plausible gene-enhancer links on Xie et al. data. a Comparison of SCEPTRE p-values to Virtual FACS significance scores. Significant SCEPTRE p-values (n=139) are colored in blue and purple, and the top 139 Virtual FACS pairs, as ranked by significance score, are colored in gray-green and purple. The two sets diverged substantially, with only 43% of pairs in shared across sets. b–d These panels are similar to the corresponding panels in Fig. 4. SCEPTRE pairs showed strong enrichment for biological signals associated with enhancer activity on b physical distance, c HIC interaction, and d ChIP-seq metrics relative to other methods

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