Fig. 5

The copy number effects. a Distribution of correlations for uncorrected gene log fold changes with their own copy number across cell lines in Achilles for common essential and nonessential genes. b Lowess smoothed trends for the mean-centered log fold change of known essential and known nonessential genes as a function of copy number. c Per-gene correlations of gene fitness effects with its own copy number, binned by mean gene fitness effect. BAGEL2’s copy correction is supplied by CRISPRCleanR. The boxes show the IQR for the correlations of genes in the given bin, whiskers extending to the last data point within 1.5 the IQR from the median