Fig. 2
Properties of cardiac-specific and ubiquitous cis-regulatory elements and their associated genes. A Schematics of the regulatory signature and the number of genes in the four categories. i: Category I; ii: Category II; iii: Category III; iv: Category IV. B Location of CREs in each Category with respect to the TSS assigned by GREAT. i and i’: promoter and enhancers in Category I; ii: promoters in Category II; iii: enhancers in Category III; iv and iv’: promoters and enhancers in Category IV. C Representative de novo-predicted motifs in each CRE Category and associated transcription factor binding sites. Motif over-representation score (Z-score) calculated with Trawler_Web [23]. i: CREs in Category I; ii: CREs in Category II; iii: CREs in Category III; iv: CREs in Category IV. D GO Plot of Gene ontology enrichment calculated with Metascape [22] for genes of each Category. Enrichment of representative GO terms is presented as log10Pvalue < − 5. i: Category I; ii: Category II; iii: Category III; iv: Category IV. TSS = transcription start site; kb = kilobase. Related to Additional file 1: Fig S3