Fig. 4

A 15 % of differentially spliced exons, between reticulated and mature platelets, are known to encode protein features. For this subset of exons, NEASE enrichment can be performed. B Gene level enrichment of all differentially spliced exons in the Reactome database fails to capture the most relevant pathways. C In contrast, NEASE shows an enrichment of the GPCR downstream signaling and other related pathways that are well known to be important in platelet activation. D A further look at the genes driving the enrichment of the GPCR pathway shows the most relevant genes affected by AS