Fig. 1

Overview of NEASE. A Annotated exons are mapped to Pfam domains, motifs, and residues. The joint graph of PPIs, DDIs, DMIs, and co-resolved structure is used to identify the interactions mediated by these features. B For a list of exons/events, NEASE identifies interactions mediated by the spliced protein features and pathways that are significantly affected by those interactions. C NEASE provides a corrected p value, in addition to an enrichment score (NEASE Score) for every pathway (see the “Methods” section). The user can further focus on an individual pathway, where NEASE can prioritize genes and find new biomarkers. In this example, the gene G3 was not part of the enriched pathway A but it has the largest number of affected interactions with genes from the pathway