Fig. 7

Proposed model of X chromosome dosage compensation during mouse iPSC reprogramming. Scheme of dosage compensation on the Xa and Xi during reprogramming of female fibroblast to iPSCs and consecutive loss of one X (XO). Events taking place on the Xa are marked in green and in red for the Xi. On the somatic state, the Xa is hyperactive and hyperaccessible compared to autosomal levels. During reprogramming, the Xa undergoes XCD and chromatin hyperaccessibility decreases until it reaches the level of autosomes in the pluripotent state. Concurrently, the Xi gains chromatin accessibility and is reactivated with different genes reactivating at different times during reprogramming. From the pluripotent state, one X chromosome can be lost, which induces upregulation of the sole Xa. The doted box shows the predicted accessibility level of the Xa in XO iPSCs