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Fig. 4 | Genome Biology

Fig. 4

From: Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals

Fig. 4

Erasure of XCU during iPSC reprogramming and XCU induction following aneuploidy of the X chromosome. A Expression ratio of the X-Mus allele (blue) and X-Cast allele (red) to autosomes (X/A) as a function of reprogramming pseudotime trajectory (left) and between cells in cluster 0 and 5 defined in Fig. 3E (right). A Wilcoxon rank-sum test used for significance testing. B Kinetics of XCU erasure on a per gene basis reconstructed using loess regression to measure X-Cast normalized expression in each cell as a function of pseudotime. The resulting inferred values at equal pseudotime intervals are classified by expression pattern using k-means clustering. C Distribution of burst frequency (left) and burst size of autosomal and X-linked genes on the Cast allele in cells from cluster 0 and 5 defined in Fig. 3E. A Wilcoxon rank-sum test used for significance testing. D X/A ratio for Cast (red) and Mus (blue) alleles. The dashed line indicates the expected X/A ratio when both X chromosome alleles are expressed like autosomal alleles

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