Fig. 1

Enhanced chromatin accessibility of the Xa in Female MEFs. A Schematic representation of the experimental design used to study allele-specific chromatin accessibility changes on the X chromosomes in female MEFs with ATAC-sequencing. B ATAC-seq signals for non-allelic (black) and allelic (Mus, blue and Cast, red) chromatin accessibility of the entire X chromosome. C Violin plot combined with boxplot showing normalized accessibility of the Xi chromosome and the median of all the autosomes (left) and fold change (FC) of the median normalized accessibility of the Xi relative to the autosomes (right) for the Mus allele in female MEFs. A Wilcoxon rank-sum test was used for significance testing. D Violin plot combined with boxplot showing normalized accessibility of the Xa chromosome and the median of all the autosomes (left) and fold change (FC) of the median normalized accessibility of the Xa relative to the autosomes (right) for the Cast allele in female MEFs. A Wilcoxon rank-sum test was used for significance testing. E Density plot with X-linked (red) and all autosomal (grey) regions from the Cast allele showing normalized accessibility in female MEFs. F Violin plot combined with boxplot showing normalized accessibility of the X chromosome and all the autosomes for the Cast allele. The dashed line indicates the median accessibility on the X-Cast