Table 1 Frequent UMGs driving high connectivity within EnrichmentMap functional clusters
From: Network propagation-based prioritization of long tail genes in 17 cancer types
Functional cluster | Frequent UMGs |
|---|---|
Known cancer-related | PIK3R2, PIK3R3, AKT1, IKBKB, MAPK1, MAPK3, PIK3CB, PIK3CD, MAP2K1, MAP2K2 |
Proliferation | CCND1, BUB1B, CDC16, ANAPC4, ANAPC7, CDC23, CDC26, CDC27, CUL3, TGFB1, AURKA, CDK1, CDK2, CDK4, CCNB1, NDC80 |
Adhesion | ITGB1, ITGB5, RHOA, SRC, ITGA2, ITGA4, VCL |
Transcription and translation | RUVBL2 |
Binding | SRC, RELA |
Immune system | TRAF6, MTOR, IRF4, IKBKB, IKBKG |
Cancer mega-pathways | CCND1, PIK3R2, PIK3R3, GRB2, EGFR, AKT1, MAPK1, MAPK3, PIK3CB, SOS1, PIK3CD, MAP2K1, MAP2K2 |
Other diseases and infection mega-pathways | CASP3, MAPK14, CASP8, PIK3R2, PIK3R3, TRAF6, AKT1, MAP3K7, IRF3, IKBKB, IKBKG, MAPK1, MAPK3, PIK3CB, RELA, MAPK8, PIK3CD, MAPK9 |